Disrupted Intercellular Communication Causes a Disfiguring Birth Defect
نویسنده
چکیده
-Glial fibrillary acidic protein (GFA) was assayed in nerve-tumour extracts and located in these tumours by indirect immunofluorescence study. We conclude that GFA is a specific marker of both malignant and normal astrocytes. Non-astrocytic tumours (oligodendroglioma, meningioma) do not contain GFA. Tumours with astrocytic differentiation potential (medulloblastoma) may contain GFA. Comparison of microscopic and GFA assays leads us to conclude that GFA concentration is proportional to the amount of malignant astrocytes in the tumour and inversely proportional to the necrotic area of a tumour. Normal tissue GFA and glioblastoma GFA were found to be immunologically identical.
منابع مشابه
Brittle Bone Disease (Osteogenesis Imperfecta)
Brittle bone disease (Osteogenesis imperfecta first defined by McKusick in 1956, is a disease that causes extremely fragile bones. It is a (OI)), congenital disease meaning that it is present during birth. It is often caused by a defect in the gene that produces type I collagen an important building block of bone and the most abundant protein found in the body. This gene can be affected in many...
متن کاملDetection of shape outliers, with an application to complete unilateral cleft lip and palate in humans
Cleft lip/palate (CLP) is a relatively common birth defect (about 1 per 1000) so disfiguring that nowadays it is almost always corrected surgically as early as possible. The postnatal surgical correction does not, however, result in a normally growing maxilla (upper jaw), but instead, owing to scar tissue and altered mechanical function, one that grows abnormally. It is of interest to determine...
متن کاملE-cadherin and cell adhesion: a role in architecture and function in the pancreatic islet.
BACKGROUND/AIMS The efficient secretion of insulin from beta-cells requires extensive intra-islet communication. The cell surface adhesion protein epithelial (E)-cadherin (ECAD) establishes and maintains epithelial tissues such as the islets of Langerhans. In this study, the role of ECAD in regulating insulin secretion from pseudoislets was investigated. METHODS The effect of an immuno-neutra...
متن کاملNasal Encephalocoele: An Atypical Case
An encephalocoele is a congenital deformity in which the intracranial contents herniate through a defect in the skull. As the defect is more attributed to embryological development, it most commonly has a mean age of presentation ranging between 15.5 and 21 months.Nasal enchephalocoeles are herniation of cranial content through a bony defect in the anterior skull base into the nasal area. They ...
متن کاملConnexin26 gap junction mediates miRNA intercellular genetic communication in the cochlea and is required for inner ear development
Organ development requires well-established intercellular communication to coordinate cell proliferations and differentiations. MicroRNAs (miRNAs) are small, non-coding RNAs that can broadly regulate gene expression and play a critical role in the organ development. In this study, we found that miRNAs could pass through gap junctions between native cochlear supporting cells to play a role in th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- PLoS Biology
دوره 4 شماره
صفحات -
تاریخ انتشار 2006